Drug interactions
Esketamine intranasal + Zolpidem
Severity: Moderate
Esketamine intranasal and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combined use can increase drowsiness, dissociation and impaired alertness. Psychomotor impairment may persist after the observation period.
What this interaction means in plain words
Esketamine intranasal and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from NMDA antagonism and GABA-A potentiation.
What to do
Avoid taking zolpidem close to esketamine sessions, monitor sedation during observation, and advise no driving until the next day.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Frequently asked questions
Can I take Esketamine intranasal with Zolpidem?
MediHelp rates the interaction as moderate. Esketamine intranasal and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so combined use can increase drowsiness, dissociation and impaired alertness. Psychomotor impairment may persist after the observation period.
How serious is the interaction between Esketamine intranasal and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking zolpidem close to esketamine sessions, monitor sedation during observation, and advise no driving until the next day.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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