Drug interactions
Estrogens conjugated synthetic + Lamotrigine
Severity: Moderate
Estrogens conjugated synthetic and Lamotrigine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens can lower lamotrigine concentrations, with a risk of loss of seizure or mood control. The effect is best documented with ethinylestradiol.
What this interaction means in plain words
Estrogens conjugated synthetic and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Estrogens induce glucuronidation of lamotrigine, increasing its clearance.
What to do
Monitor clinical response or lamotrigine levels when starting or stopping estrogen therapy. Adjust the lamotrigine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Frequently asked questions
Can I take Estrogens conjugated synthetic with Lamotrigine?
MediHelp rates the interaction as moderate. Estrogens conjugated synthetic and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estrogens can lower lamotrigine concentrations, with a risk of loss of seizure or mood control. The effect is best documented with ethinylestradiol.
How serious is the interaction between Estrogens conjugated synthetic and Lamotrigine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response or lamotrigine levels when starting or stopping estrogen therapy. Adjust the lamotrigine dose as needed.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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