Drug interactions
Estropipate + Heparin
Severity: Major
Estropipate and Heparin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estropipate increases clotting factor production and thrombotic risk, working against anticoagulant therapy. It should be avoided in active thromboembolic disease.
What this interaction means in plain words
Estropipate and Heparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Estrogen-induced prothrombotic state opposes heparin.
What to do
Stop estropipate during treatment of acute thrombosis and monitor anticoagulant response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Estropipate with Heparin?
MediHelp rates the interaction as major. Estropipate and Heparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Estropipate increases clotting factor production and thrombotic risk, working against anticoagulant therapy. It should be avoided in active thromboembolic disease.
How serious is the interaction between Estropipate and Heparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop estropipate during treatment of acute thrombosis and monitor anticoagulant response.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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