Drug interactions
ethinyl estradiol (combined ocp) + rifampin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↓ contraceptive efficacy → pregnancy risk.
Mechanism of action
CYP3A induction.
Clinical management
Use non-hormonal or higher-dose/alternative contraception.
References
Frequently asked questions
Can I take ethinyl estradiol (combined ocp) with rifampin?
The interaction is rated: Major. ↓ contraceptive efficacy → pregnancy risk.
How serious is the interaction between ethinyl estradiol (combined ocp) and rifampin?
The interaction is rated: Major. Evidence level: High.
How is the interaction between ethinyl estradiol (combined ocp) and rifampin managed?
Use non-hormonal or higher-dose/alternative contraception.
Why do ethinyl estradiol (combined ocp) and rifampin interact?
CYP3A induction.
Full monographs, dosing and an interaction checker in the MediHelp app
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