Drug interactions
Ethinyl estradiol-levonorgestrel + Exenatide injectable
Severity: Minor
Ethinyl estradiol-levonorgestrel and Exenatide injectable: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exenatide slows gastric emptying and may reduce the rate and extent of absorption of oral medicines such as contraceptives. Estrogen-progestin contraceptives can also modestly impair glucose tolerance, which may offset exenatide's glycemic benefit. Both effects are generally small.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Exenatide injectable have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Delayed gastric emptying by exenatide alters oral absorption, and contraceptive steroids reduce insulin sensitivity.
What to do
Advise taking the contraceptive at least 1 hour before exenatide injection. Monitor glycemic control when starting or stopping the contraceptive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Exenatide injectable?
MediHelp rates the interaction as minor. Ethinyl estradiol-levonorgestrel and Exenatide injectable have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Exenatide slows gastric emptying and may reduce the rate and extent of absorption of oral medicines such as contraceptives. Estrogen-progestin contraceptives can also modestly impair glucose tolerance, which may offset exenatide's glycemic benefit. Both effects are generally small.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Exenatide injectable?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise taking the contraceptive at least 1 hour before exenatide injection. Monitor glycemic control when starting or stopping the contraceptive.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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