Drug interactions
Ethinyl estradiol-levonorgestrel + Insulin inhaled
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Insulin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hormonal contraceptives can slightly worsen glucose tolerance, which may reduce the glucose-lowering effect of inhaled insulin. Larger insulin doses may occasionally be required.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Insulin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through reduced insulin sensitivity caused by estrogen and progestin.
What to do
Monitor glucose closely after starting or stopping the contraceptive and titrate the insulin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Insulin inhaled?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Insulin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hormonal contraceptives can slightly worsen glucose tolerance, which may reduce the glucose-lowering effect of inhaled insulin. Larger insulin doses may occasionally be required.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Insulin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely after starting or stopping the contraceptive and titrate the insulin dose accordingly.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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