Drug interactions
Ethinyl estradiol-levonorgestrel + Lonapegsomatropin
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Lonapegsomatropin: moderate interaction.
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For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral estrogens reduce hepatic IGF-1 production in response to growth hormone, which can blunt the effect of lonapegsomatropin. Higher growth hormone doses may be needed in patients taking oral estrogens.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Lonapegsomatropin belongs to Endocrine.
Why it happens
First-pass hepatic estrogen exposure suppresses growth hormone-stimulated IGF-1 generation.
What to do
Monitor IGF-1 and growth response, and increase the lonapegsomatropin dose if needed; reassess when the estrogen is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Lonapegsomatropin?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral estrogens reduce hepatic IGF-1 production in response to growth hormone, which can blunt the effect of lonapegsomatropin. Higher growth hormone doses may be needed in patients taking oral estrogens.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Lonapegsomatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor IGF-1 and growth response, and increase the lonapegsomatropin dose if needed; reassess when the estrogen is started or stopped.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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