Drug interactions
Ethinyl estradiol-levonorgestrel + Olanzapine
Severity: Minor
Ethinyl estradiol-levonorgestrel and Olanzapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP1A2 inhibitor and may modestly raise olanzapine concentrations. This may increase sedation or metabolic and anticholinergic effects, though the change is usually small.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Weak CYP1A2 inhibition by ethinyl estradiol reduces olanzapine clearance.
What to do
Monitor for sedation and other olanzapine adverse effects when the contraceptive is started, and reduce the olanzapine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Olanzapine?
MediHelp rates the interaction as minor. Ethinyl estradiol-levonorgestrel and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol is a weak CYP1A2 inhibitor and may modestly raise olanzapine concentrations. This may increase sedation or metabolic and anticholinergic effects, though the change is usually small.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Olanzapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and other olanzapine adverse effects when the contraceptive is started, and reduce the olanzapine dose if they occur.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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