Drug interactions
Ethinyl estradiol-levonorgestrel + Selegiline transdermal
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Selegiline transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptives can raise selegiline concentrations, which may amplify its effects. With transdermal selegiline used for depression, this could increase adverse effects such as blood pressure changes, insomnia or dizziness.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ethinyl estradiol-containing contraceptives are thought to inhibit hepatic metabolism of selegiline, raising its exposure.
What to do
Monitor blood pressure and for selegiline adverse effects when starting or stopping the contraceptive. Reduce the selegiline dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Selegiline transdermal?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral contraceptives can raise selegiline concentrations, which may amplify its effects. With transdermal selegiline used for depression, this could increase adverse effects such as blood pressure changes, insomnia or dizziness.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Selegiline transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for selegiline adverse effects when starting or stopping the contraceptive. Reduce the selegiline dose if adverse effects develop.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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