Drug interactions
Ethinyl estradiol-levonorgestrel + Valoctocogene roxaparvovec
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Valoctocogene roxaparvovec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valoctocogene roxaparvovec commonly causes transaminase elevations, and other hepatotoxic or hepatically active drugs may add to this. Hormonal contraceptives can affect liver enzymes and complicate interpretation of liver monitoring.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Valoctocogene roxaparvovec belongs to Miscellaneous.
Why it happens
Additive potential for hepatic injury; the gene therapy is delivered to hepatocytes and liver enzyme elevation is a known effect.
What to do
Monitor ALT and other liver tests closely after gene therapy. Review need for the contraceptive or consider alternatives if liver enzymes rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinyl estradiol-levonorgestrel and Valoctocogene roxaparvovec, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Valoctocogene roxaparvovec
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec commonly causes transaminase elevations, and other hepatotoxic or hepatically active drugs may add to this. Hormonal contraceptives can affect liver enzymes and complicate interpretation of liver monitoring.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT and other liver tests closely after gene therapy. Review need for the contraceptive or consider alternatives if liver enzymes rise.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
