Drug interactions
Ethinyl estradiol-norgestimate + Exenatide injectable
Severity: Moderate
Ethinyl estradiol-norgestimate and Exenatide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exenatide slows gastric emptying and may reduce the rate and extent of absorption of oral drugs, including oral contraceptives. Estrogen-containing contraceptives can also modestly impair glucose tolerance, partly opposing the glucose-lowering effect of exenatide.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Exenatide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Delayed gastric emptying by exenatide reduces oral drug absorption, and estrogen-induced insulin resistance antagonizes glycemic control.
What to do
Take the oral contraceptive at least 1 hour before exenatide injection. Monitor glycemic control when starting or stopping the contraceptive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Exenatide injectable?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Exenatide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Exenatide slows gastric emptying and may reduce the rate and extent of absorption of oral drugs, including oral contraceptives. Estrogen-containing contraceptives can also modestly impair glucose tolerance, partly opposing the glucose-lowering effect of exenatide.
How serious is the interaction between Ethinyl estradiol-norgestimate and Exenatide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take the oral contraceptive at least 1 hour before exenatide injection. Monitor glycemic control when starting or stopping the contraceptive.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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