Drug interactions
Ethinyl estradiol-norgestimate + Insulin aspart
Severity: Moderate
Ethinyl estradiol-norgestimate and Insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined hormonal contraceptives can slightly impair glucose tolerance and insulin sensitivity, so insulin requirements may rise. With modern low-dose products the effect is small but can matter in diabetes.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-norgestimate belongs to Endocrine; Insulin aspart belongs to Endocrine.
Why it happens
Estrogen and progestin effects on insulin sensitivity oppose insulin action, a pharmacodynamic antagonism.
What to do
Monitor blood glucose more closely when starting or stopping the contraceptive and adjust insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Insulin aspart
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Insulin aspart?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined hormonal contraceptives can slightly impair glucose tolerance and insulin sensitivity, so insulin requirements may rise. With modern low-dose products the effect is small but can matter in diabetes.
How serious is the interaction between Ethinyl estradiol-norgestimate and Insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more closely when starting or stopping the contraceptive and adjust insulin dose as needed.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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