Drug interactions
Ethinyl estradiol-norgestimate + Nefazodone
Severity: Minor
Ethinyl estradiol-norgestimate and Nefazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a potent CYP3A4 inhibitor and may raise ethinyl estradiol and progestin concentrations. This can increase estrogenic adverse effects such as nausea, breast tenderness and breakthrough bleeding. The clinical effect is usually modest.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nefazodone inhibits CYP3A4, reducing the metabolism of ethinyl estradiol and norgestimate metabolites.
What to do
Monitor for estrogenic adverse effects and blood pressure. Consider a lower-estrogen formulation if effects are troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinyl estradiol-norgestimate and Nefazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Nefazodone?
MediHelp rates the interaction as minor. Ethinyl estradiol-norgestimate and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nefazodone is a potent CYP3A4 inhibitor and may raise ethinyl estradiol and progestin concentrations. This can increase estrogenic adverse effects such as nausea, breast tenderness and breakthrough bleeding. The clinical effect is usually modest.
How serious is the interaction between Ethinyl estradiol-norgestimate and Nefazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects and blood pressure. Consider a lower-estrogen formulation if effects are troublesome.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
