Drug interactions
Ethinyl estradiol-norgestimate + Selegiline transdermal
Severity: Moderate
Ethinyl estradiol-norgestimate and Selegiline transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptives have been reported to increase selegiline exposure, likely by reducing its metabolism. With transdermal selegiline, which bypasses first-pass metabolism, the effect is expected to be limited but may increase MAO inhibitor effects such as blood pressure changes.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of selegiline N-demethylation by ethinyl estradiol-containing contraceptives.
What to do
Monitor blood pressure and for adverse effects of selegiline when starting or stopping the contraceptive. Adjust the selegiline dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Selegiline transdermal?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral contraceptives have been reported to increase selegiline exposure, likely by reducing its metabolism. With transdermal selegiline, which bypasses first-pass metabolism, the effect is expected to be limited but may increase MAO inhibitor effects such as blood pressure changes.
How serious is the interaction between Ethinyl estradiol-norgestimate and Selegiline transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for adverse effects of selegiline when starting or stopping the contraceptive. Adjust the selegiline dose if needed.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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