Drug interactions
Ethinylestradiol + Glimepiride-pioglitazone
Severity: Moderate
Ethinylestradiol and Glimepiride-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone labeling reports reduced ethinylestradiol exposure with coadministration, which could lower the reliability of hormonal contraception. The clinical significance is uncertain but contraceptive efficacy may be reduced. Glimepiride is not expected to contribute.
What this interaction means in plain words
Ethinylestradiol and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not established; pioglitazone may induce metabolism of ethinylestradiol.
What to do
Counsel women using combined oral contraceptives about possible reduced efficacy and consider an additional or alternative contraceptive method.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Frequently asked questions
Can I take Ethinylestradiol with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Ethinylestradiol and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pioglitazone labeling reports reduced ethinylestradiol exposure with coadministration, which could lower the reliability of hormonal contraception. The clinical significance is uncertain but contraceptive efficacy may be reduced. Glimepiride is not expected to contribute.
How serious is the interaction between Ethinylestradiol and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel women using combined oral contraceptives about possible reduced efficacy and consider an additional or alternative contraceptive method.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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