Drug interactions
Ethinylestradiol + Metformin-sitagliptin
Severity: Minor
Ethinylestradiol and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinylestradiol, especially in older higher-dose products, can reduce glucose tolerance and insulin sensitivity. Antidiabetic effectiveness may be slightly reduced in some patients.
What this interaction means in plain words
Ethinylestradiol and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Estrogen effects on insulin sensitivity and glucose tolerance may oppose antidiabetic effect.
What to do
Monitor blood glucose when starting or stopping ethinylestradiol-containing products and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Frequently asked questions
Can I take Ethinylestradiol with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Ethinylestradiol and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinylestradiol, especially in older higher-dose products, can reduce glucose tolerance and insulin sensitivity. Antidiabetic effectiveness may be slightly reduced in some patients.
How serious is the interaction between Ethinylestradiol and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping ethinylestradiol-containing products and adjust antidiabetic therapy if needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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