Drug interactions
Ethiodized oil + Metformin
Severity: Moderate
Ethiodized oil and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethiodized oil is an iodinated contrast agent. Although mostly used in lymphography and hepatic chemoembolization, it carries some systemic iodinated contrast exposure, and renal injury could lead to metformin accumulation and lactic acidosis.
What this interaction means in plain words
Ethiodized oil and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible contrast-related decline in renal function reduces metformin elimination.
What to do
In patients with renal impairment or intra-arterial administration, hold metformin at the time of the procedure and for 48 hours afterward. Check renal function before restarting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Frequently asked questions
Can I take Ethiodized oil with Metformin?
MediHelp rates the interaction as moderate. Ethiodized oil and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethiodized oil is an iodinated contrast agent. Although mostly used in lymphography and hepatic chemoembolization, it carries some systemic iodinated contrast exposure, and renal injury could lead to metformin accumulation and lactic acidosis.
How serious is the interaction between Ethiodized oil and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients with renal impairment or intra-arterial administration, hold metformin at the time of the procedure and for 48 hours afterward. Check renal function before restarting.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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