Drug interactions
Ethosuximide + Midazolam intranasal
Severity: Moderate
Ethosuximide and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a benzodiazepine with significant respiratory and CNS depressant effects, and ethosuximide adds sedation. The combination may increase the risk of hypoventilation, oversedation and prolonged recovery.
What this interaction means in plain words
Ethosuximide and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant pharmacodynamic effects.
What to do
Monitor respiratory status and level of consciousness after intranasal midazolam, and have resuscitation support available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Frequently asked questions
Can I take Ethosuximide with Midazolam intranasal?
MediHelp rates the interaction as moderate. Ethosuximide and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam is a benzodiazepine with significant respiratory and CNS depressant effects, and ethosuximide adds sedation. The combination may increase the risk of hypoventilation, oversedation and prolonged recovery.
How serious is the interaction between Ethosuximide and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory status and level of consciousness after intranasal midazolam, and have resuscitation support available.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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