Drug interactions
Etoposide + Influenza virus vaccine trivalent adjuvanted
Severity: Moderate
Etoposide and Influenza virus vaccine trivalent adjuvanted: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etoposide-related myelosuppression and immunosuppression can blunt the antibody response to influenza vaccine. The vaccine is inactivated and remains safe, so vaccination is still generally recommended.
What this interaction means in plain words
Etoposide and Influenza virus vaccine trivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression reduces vaccine immunogenicity.
What to do
Vaccinate ideally before starting chemotherapy or between cycles when counts are recovering. Do not withhold vaccination if timing cannot be optimized.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Etoposide with Influenza virus vaccine trivalent adjuvanted?
MediHelp rates the interaction as moderate. Etoposide and Influenza virus vaccine trivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etoposide-related myelosuppression and immunosuppression can blunt the antibody response to influenza vaccine. The vaccine is inactivated and remains safe, so vaccination is still generally recommended.
How serious is the interaction between Etoposide and Influenza virus vaccine trivalent adjuvanted?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate ideally before starting chemotherapy or between cycles when counts are recovering. Do not withhold vaccination if timing cannot be optimized.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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