Drug interactions
Etoposide + Isoniazid
Severity: Minor
Etoposide and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etoposide is partly cleared by CYP3A4 and isoniazid may weakly inhibit this pathway. Exposure may increase slightly, potentially worsening myelosuppression. Documented clinical impact is minimal.
What this interaction means in plain words
Etoposide and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etoposide belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Theoretical weak CYP3A4 inhibition by isoniazid reducing etoposide clearance.
What to do
Monitor blood counts as part of routine chemotherapy care. No dose change is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Etoposide with Isoniazid?
MediHelp rates the interaction as minor. Etoposide and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etoposide is partly cleared by CYP3A4 and isoniazid may weakly inhibit this pathway. Exposure may increase slightly, potentially worsening myelosuppression. Documented clinical impact is minimal.
How serious is the interaction between Etoposide and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts as part of routine chemotherapy care. No dose change is usually required.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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