Drug interactions
Etoposide + Meningococcal group b vaccine
Severity: Moderate
Etoposide and Meningococcal group b vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etoposide-induced myelosuppression and immunosuppression may blunt the antibody response to the meningococcal B vaccine. Patients may remain inadequately protected.
What this interaction means in plain words
Etoposide and Meningococcal group b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression impairs the immune response to vaccination.
What to do
Vaccinate, if possible, at least two weeks before chemotherapy or after immune recovery. Consider revaccination or antibody testing if given during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Etoposide with Meningococcal group b vaccine?
MediHelp rates the interaction as moderate. Etoposide and Meningococcal group b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etoposide-induced myelosuppression and immunosuppression may blunt the antibody response to the meningococcal B vaccine. Patients may remain inadequately protected.
How serious is the interaction between Etoposide and Meningococcal group b vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate, if possible, at least two weeks before chemotherapy or after immune recovery. Consider revaccination or antibody testing if given during treatment.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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