Drug interactions
Etoposide + Nafcillin
Severity: Minor
Etoposide and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin may modestly induce CYP3A4 and could lower etoposide concentrations. The clinical effect is not well characterized but reduced efficacy is possible.
What this interaction means in plain words
Etoposide and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nafcillin is a weak CYP3A4 inducer that may increase etoposide metabolism.
What to do
Monitor treatment response when nafcillin is given during etoposide therapy. No empirical dose change is generally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Etoposide with Nafcillin?
MediHelp rates the interaction as minor. Etoposide and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin may modestly induce CYP3A4 and could lower etoposide concentrations. The clinical effect is not well characterized but reduced efficacy is possible.
How serious is the interaction between Etoposide and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response when nafcillin is given during etoposide therapy. No empirical dose change is generally needed.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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