Drug interactions
Etoposide + Sipuleucel-t
Severity: Moderate
Etoposide and Sipuleucel-t: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etoposide is a cytotoxic, myelosuppressive agent and may impair the immune cell activation that sipuleucel-T relies on. This may reduce the efficacy of the immunotherapy.
What this interaction means in plain words
Etoposide and Sipuleucel-t can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: cytotoxic suppression of immune cells reduces the immune response induced by sipuleucel-T.
What to do
Avoid giving chemotherapy around leukapheresis and infusion where possible. Consider the likely reduced benefit if etoposide is essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Etoposide with Sipuleucel-t?
MediHelp rates the interaction as moderate. Etoposide and Sipuleucel-t can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etoposide is a cytotoxic, myelosuppressive agent and may impair the immune cell activation that sipuleucel-T relies on. This may reduce the efficacy of the immunotherapy.
How serious is the interaction between Etoposide and Sipuleucel-t?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving chemotherapy around leukapheresis and infusion where possible. Consider the likely reduced benefit if etoposide is essential.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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