Drug interactions
Eucalyptus + Phenytoin
Severity: Minor
Eucalyptus and Phenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces CYP3A4 and may speed the breakdown of eucalyptus constituents metabolized by this enzyme, reducing their effect. The clinical relevance is unclear and likely small.
What this interaction means in plain words
Eucalyptus and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Phenytoin induction of CYP3A4 may increase metabolism of eucalyptus components.
What to do
No routine action is required; be aware that herbal effect may be diminished.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Eucalyptus with Phenytoin?
MediHelp rates the interaction as minor. Eucalyptus and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenytoin induces CYP3A4 and may speed the breakdown of eucalyptus constituents metabolized by this enzyme, reducing their effect. The clinical relevance is unclear and likely small.
How serious is the interaction between Eucalyptus and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is required; be aware that herbal effect may be diminished.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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