Drug interactions
Exemestane + Griseofulvin
Severity: Moderate
Exemestane and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may reduce exemestane exposure, potentially weakening its aromatase-inhibiting effect in breast cancer treatment. Exemestane labeling recommends a dose increase with potent CYP3A4 inducers.
What this interaction means in plain words
Exemestane and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Exemestane belongs to Oncology; Griseofulvin belongs to Anti Fungals.
Why it happens
Griseofulvin induces CYP3A4, which increases exemestane metabolism.
What to do
Consider raising exemestane to 50 mg daily after a meal during concurrent therapy, or use an antifungal without inducing activity. Revert to the usual dose after griseofulvin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Exemestane
Frequently asked questions
Can I take Exemestane with Griseofulvin?
MediHelp rates the interaction as moderate. Exemestane and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin may reduce exemestane exposure, potentially weakening its aromatase-inhibiting effect in breast cancer treatment. Exemestane labeling recommends a dose increase with potent CYP3A4 inducers.
How serious is the interaction between Exemestane and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider raising exemestane to 50 mg daily after a meal during concurrent therapy, or use an antifungal without inducing activity. Revert to the usual dose after griseofulvin is stopped.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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