Drug interactions
Exenatide injectable + Insulin aspart-insulin aspart protamine
Severity: Moderate
Exenatide injectable and Insulin aspart-insulin aspart protamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exenatide combined with insulin increases the risk of hypoglycemia because both lower blood glucose. Labeling advises caution when they are combined.
What this interaction means in plain words
Exenatide injectable and Insulin aspart-insulin aspart protamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose-lowering effects of GLP-1 receptor agonism and exogenous insulin.
What to do
Monitor blood glucose and consider lowering the insulin dose when starting exenatide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Frequently asked questions
Can I take Exenatide injectable with Insulin aspart-insulin aspart protamine?
MediHelp rates the interaction as moderate. Exenatide injectable and Insulin aspart-insulin aspart protamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Exenatide combined with insulin increases the risk of hypoglycemia because both lower blood glucose. Labeling advises caution when they are combined.
How serious is the interaction between Exenatide injectable and Insulin aspart-insulin aspart protamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and consider lowering the insulin dose when starting exenatide.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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