Drug interactions
Fenbufen + Hydrochlorothiazide-olmesartan
Severity: Moderate
Fenbufen and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenbufen is an NSAID that can reduce renal prostaglandin synthesis, blunting the antihypertensive effect of olmesartan and diuretics. In volume-depleted, elderly, or renally impaired patients, the combination can cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Fenbufen and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins reduces glomerular perfusion and sodium excretion, which, with RAS blockade and diuretics, impairs renal function and potassium excretion.
What to do
Avoid prolonged NSAID use where possible; ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium after starting and during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Fenbufen with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Fenbufen and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenbufen is an NSAID that can reduce renal prostaglandin synthesis, blunting the antihypertensive effect of olmesartan and diuretics. In volume-depleted, elderly, or renally impaired patients, the combination can cause acute kidney injury and hyperkalemia.
How serious is the interaction between Fenbufen and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged NSAID use where possible; ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium after starting and during therapy.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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