Drug interactions
Fenbufen + Propranolol
Severity: Moderate
Fenbufen and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenbufen can blunt the antihypertensive effect of beta blockers through sodium and fluid retention and reduced prostaglandin synthesis. Blood pressure control may worsen with prolonged use.
What this interaction means in plain words
Fenbufen and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes fluid retention and opposes antihypertensive action.
What to do
Monitor blood pressure when an NSAID is used for more than a few days. Use the lowest effective NSAID dose for the shortest time or consider an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Fenbufen with Propranolol?
MediHelp rates the interaction as moderate. Fenbufen and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenbufen can blunt the antihypertensive effect of beta blockers through sodium and fluid retention and reduced prostaglandin synthesis. Blood pressure control may worsen with prolonged use.
How serious is the interaction between Fenbufen and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when an NSAID is used for more than a few days. Use the lowest effective NSAID dose for the shortest time or consider an alternative analgesic.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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