Drug interactions
Fenbufen + Telmisartan
Severity: Moderate
Fenbufen and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenbufen can blunt the antihypertensive effect of telmisartan and reduce renal function, especially in elderly or volume-depleted patients. The combination also raises the risk of hyperkalemia and acute kidney injury.
What this interaction means in plain words
Fenbufen and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, while ARB-mediated aldosterone suppression adds to potassium retention.
What to do
Monitor blood pressure, serum creatinine and potassium after starting the combination and periodically afterward. Ensure adequate hydration and use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Fenbufen with Telmisartan?
MediHelp rates the interaction as moderate. Fenbufen and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenbufen can blunt the antihypertensive effect of telmisartan and reduce renal function, especially in elderly or volume-depleted patients. The combination also raises the risk of hyperkalemia and acute kidney injury.
How serious is the interaction between Fenbufen and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting the combination and periodically afterward. Ensure adequate hydration and use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
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