Drug interactions
Fenbufen + Venlafaxine
Severity: Moderate
Fenbufen and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenbufen, an NSAID, inhibits platelet function and can injure gastric mucosa, while venlafaxine impairs platelet serotonin uptake. Together they raise the risk of gastrointestinal bleeding.
What this interaction means in plain words
Fenbufen and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet dysfunction plus NSAID-related mucosal injury.
What to do
Monitor for gastrointestinal bleeding and use the lowest effective NSAID dose for the shortest duration. Consider a proton pump inhibitor in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Fenbufen with Venlafaxine?
MediHelp rates the interaction as moderate. Fenbufen and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenbufen, an NSAID, inhibits platelet function and can injure gastric mucosa, while venlafaxine impairs platelet serotonin uptake. Together they raise the risk of gastrointestinal bleeding.
How serious is the interaction between Fenbufen and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal bleeding and use the lowest effective NSAID dose for the shortest duration. Consider a proton pump inhibitor in high-risk patients.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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