Drug interactions
Fenofibrate micronized + Pitavastatin
Severity: Moderate
Fenofibrate micronized and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates combined with statins may increase the risk of myopathy and rhabdomyolysis, as both can cause muscle toxicity. Fenofibrate carries a lower risk than gemfibrozil and has little pharmacokinetic effect on pitavastatin.
What this interaction means in plain words
Fenofibrate micronized and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic myotoxicity; fenofibrate has minimal effect on statin glucuronidation or uptake.
What to do
Combine only when lipid targets justify it, using the lowest effective doses. Counsel the patient to report muscle symptoms and check CK if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Frequently asked questions
Can I take Fenofibrate micronized with Pitavastatin?
MediHelp rates the interaction as moderate. Fenofibrate micronized and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fibrates combined with statins may increase the risk of myopathy and rhabdomyolysis, as both can cause muscle toxicity. Fenofibrate carries a lower risk than gemfibrozil and has little pharmacokinetic effect on pitavastatin.
How serious is the interaction between Fenofibrate micronized and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Combine only when lipid targets justify it, using the lowest effective doses. Counsel the patient to report muscle symptoms and check CK if they occur.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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