Drug interactions
Fenoldopam + Propranolol
Severity: Moderate
Fenoldopam and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoldopam is a potent intravenous vasodilator, and beta-blockers add to its blood pressure lowering. Beta-blockade can also blunt the reflex tachycardia that fenoldopam normally causes, leading to marked hypotension.
What this interaction means in plain words
Fenoldopam and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects, with beta-blockade blunting fenoldopam reflex tachycardia.
What to do
Titrate fenoldopam with continuous blood pressure monitoring. Avoid concurrent IV beta-blockers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Fenoldopam with Propranolol?
MediHelp rates the interaction as moderate. Fenoldopam and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoldopam is a potent intravenous vasodilator, and beta-blockers add to its blood pressure lowering. Beta-blockade can also blunt the reflex tachycardia that fenoldopam normally causes, leading to marked hypotension.
How serious is the interaction between Fenoldopam and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate fenoldopam with continuous blood pressure monitoring. Avoid concurrent IV beta-blockers.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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