Drug interactions
Fenoprofen + Feverfew
Severity: Moderate
Fenoprofen and Feverfew: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Feverfew inhibits platelet aggregation in laboratory studies, so with an NSAID it could increase bleeding tendency. Clinical reports are limited.
What this interaction means in plain words
Fenoprofen and Feverfew can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects, with feverfew parthenolide inhibiting platelet function.
What to do
Discourage concurrent use of feverfew supplements and monitor for bruising or bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Feverfew?
MediHelp rates the interaction as moderate. Fenoprofen and Feverfew can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Feverfew inhibits platelet aggregation in laboratory studies, so with an NSAID it could increase bleeding tendency. Clinical reports are limited.
How serious is the interaction between Fenoprofen and Feverfew?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discourage concurrent use of feverfew supplements and monitor for bruising or bleeding.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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