Drug interactions
Fenoprofen + Glimepiride-pioglitazone
Severity: Moderate
Fenoprofen and Glimepiride-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen may increase the hypoglycemic effect of glimepiride. The interaction is usually mild but can cause hypoglycemia in susceptible patients.
What this interaction means in plain words
Fenoprofen and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Possible protein-binding displacement and prostaglandin-related effects on insulin secretion; mechanism not firmly established.
What to do
Monitor blood glucose when the NSAID is started or stopped and reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Fenoprofen and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoprofen may increase the hypoglycemic effect of glimepiride. The interaction is usually mild but can cause hypoglycemia in susceptible patients.
How serious is the interaction between Fenoprofen and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when the NSAID is started or stopped and reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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