Drug interactions
Fenoprofen + Hydrocortisone
Severity: Moderate
Fenoprofen and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent corticosteroid and NSAID use increases the likelihood of peptic ulceration and gastrointestinal bleeding. The risk is higher with higher doses, longer duration, older age, or a history of ulcer disease.
What this interaction means in plain words
Fenoprofen and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Hydrocortisone belongs to Endocrine.
Why it happens
Additive gastrointestinal mucosal injury from prostaglandin inhibition by the NSAID and impaired mucosal repair from the corticosteroid.
What to do
Limit dose and duration of both agents and add gastroprotection with a proton pump inhibitor in high-risk patients. Monitor for signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fenoprofen and Hydrocortisone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Hydrocortisone?
MediHelp rates the interaction as moderate. Fenoprofen and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent corticosteroid and NSAID use increases the likelihood of peptic ulceration and gastrointestinal bleeding. The risk is higher with higher doses, longer duration, older age, or a history of ulcer disease.
How serious is the interaction between Fenoprofen and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit dose and duration of both agents and add gastroprotection with a proton pump inhibitor in high-risk patients. Monitor for signs of GI bleeding.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
