Drug interactions
Fenoprofen + Indapamide
Severity: Moderate
Fenoprofen and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen can reduce the antihypertensive and diuretic effect of indapamide. The combination may also raise the risk of renal impairment, especially with dehydration or in older patients.
What this interaction means in plain words
Fenoprofen and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Indapamide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and fluid retention and reduced renal blood flow.
What to do
Monitor blood pressure and renal function, and keep the patient well hydrated. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Indapamide
Frequently asked questions
Can I take Fenoprofen with Indapamide?
MediHelp rates the interaction as moderate. Fenoprofen and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoprofen can reduce the antihypertensive and diuretic effect of indapamide. The combination may also raise the risk of renal impairment, especially with dehydration or in older patients.
How serious is the interaction between Fenoprofen and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function, and keep the patient well hydrated. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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