Drug interactions
Fenoprofen + Mipomersen
Severity: Moderate
Fenoprofen and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen commonly raises serum transaminases and can cause hepatic steatosis, and NSAIDs such as fenoprofen can also cause liver enzyme elevations or, rarely, liver injury. Using both may make liver toxicity harder to detect and may add to hepatic risk.
What this interaction means in plain words
Fenoprofen and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxic potential of the two drugs; no pharmacokinetic interaction is established.
What to do
Monitor ALT, AST and bilirubin at baseline and regularly during combined use. Interrupt fenoprofen or mipomersen if enzymes rise significantly or symptoms of liver injury appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Mipomersen?
MediHelp rates the interaction as moderate. Fenoprofen and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen commonly raises serum transaminases and can cause hepatic steatosis, and NSAIDs such as fenoprofen can also cause liver enzyme elevations or, rarely, liver injury. Using both may make liver toxicity harder to detect and may add to hepatic risk.
How serious is the interaction between Fenoprofen and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin at baseline and regularly during combined use. Interrupt fenoprofen or mipomersen if enzymes rise significantly or symptoms of liver injury appear.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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