Drug interactions
Fenoprofen + Mycophenolate
Severity: Moderate
Fenoprofen and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen may raise exposure to mycophenolic acid glucuronide, and NSAIDs can add to gastrointestinal irritation and renal effects in transplant patients. The combination may increase the risk of adverse effects such as GI bleeding or renal impairment.
What this interaction means in plain words
Fenoprofen and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion of anionic compounds, plus additive GI and renal toxicity.
What to do
Monitor renal function, blood counts and GI symptoms. Prefer paracetamol for analgesia where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Mycophenolate?
MediHelp rates the interaction as moderate. Fenoprofen and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoprofen may raise exposure to mycophenolic acid glucuronide, and NSAIDs can add to gastrointestinal irritation and renal effects in transplant patients. The combination may increase the risk of adverse effects such as GI bleeding or renal impairment.
How serious is the interaction between Fenoprofen and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, blood counts and GI symptoms. Prefer paracetamol for analgesia where possible.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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