Drug interactions
Fenoprofen + Nefazodone
Severity: Moderate
Fenoprofen and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone inhibits serotonin reuptake and platelet function can be impaired, so combined with an NSAID the risk of upper gastrointestinal bleeding is increased. The risk is higher in older patients and those with ulcer history or on anticoagulants.
What this interaction means in plain words
Fenoprofen and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet aggregation (reduced platelet serotonin) and NSAID-induced mucosal injury.
What to do
Avoid the combination in high-risk patients, or add gastroprotection with a proton pump inhibitor. Monitor for signs of GI bleeding such as melena or anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Nefazodone?
MediHelp rates the interaction as moderate. Fenoprofen and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone inhibits serotonin reuptake and platelet function can be impaired, so combined with an NSAID the risk of upper gastrointestinal bleeding is increased. The risk is higher in older patients and those with ulcer history or on anticoagulants.
How serious is the interaction between Fenoprofen and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in high-risk patients, or add gastroprotection with a proton pump inhibitor. Monitor for signs of GI bleeding such as melena or anemia.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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