Drug interactions
Fenoprofen + Olmesartan
Severity: Moderate
Fenoprofen and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen can reduce the antihypertensive effect of olmesartan. In elderly, dehydrated or renally impaired patients the combination can precipitate acute kidney injury and hyperkalemia.
What this interaction means in plain words
Fenoprofen and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Olmesartan belongs to Cardiovascular.
Why it happens
NSAIDs reduce vasodilatory renal prostaglandins, impairing glomerular perfusion already dependent on angiotensin blockade, and cause sodium retention.
What to do
Monitor blood pressure, creatinine and potassium after starting the NSAID and periodically. Maintain hydration and limit NSAID duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Fenoprofen with Olmesartan?
MediHelp rates the interaction as moderate. Fenoprofen and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoprofen can reduce the antihypertensive effect of olmesartan. In elderly, dehydrated or renally impaired patients the combination can precipitate acute kidney injury and hyperkalemia.
How serious is the interaction between Fenoprofen and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium after starting the NSAID and periodically. Maintain hydration and limit NSAID duration.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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