Drug interactions
Fenoprofen + Parecoxib
Severity: Major
Fenoprofen and Parecoxib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is a COX-2 inhibitor prodrug, so combining it with a nonselective NSAID duplicates therapy. This increases the risk of gastrointestinal bleeding, renal impairment, fluid retention, hyperkalemia and cardiovascular events without added benefit.
What this interaction means in plain words
Fenoprofen and Parecoxib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate cyclooxygenase inhibition with additive effects on gastric mucosa, renal prostaglandins and platelets.
What to do
Avoid concurrent use of two NSAIDs; choose one agent at the lowest effective dose. Monitor renal function and potassium if overlap is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fenoprofen and Parecoxib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Parecoxib?
MediHelp rates the interaction as major. Fenoprofen and Parecoxib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Parecoxib is a COX-2 inhibitor prodrug, so combining it with a nonselective NSAID duplicates therapy. This increases the risk of gastrointestinal bleeding, renal impairment, fluid retention, hyperkalemia and cardiovascular events without added benefit.
How serious is the interaction between Fenoprofen and Parecoxib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two NSAIDs; choose one agent at the lowest effective dose. Monitor renal function and potassium if overlap is unavoidable.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
