Drug interactions
Fenoprofen + Phenindione
Severity: Major
Fenoprofen and Phenindione: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenindione is a vitamin K antagonist, and fenoprofen impairs platelet function and can cause gastrointestinal bleeding. The combination increases the risk of serious bleeding.
What this interaction means in plain words
Fenoprofen and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment: vitamin K antagonism plus NSAID platelet inhibition and mucosal injury, with possible protein-binding displacement.
What to do
Avoid NSAIDs in patients taking oral anticoagulants where possible and use acetaminophen instead. If combined, monitor INR and bleeding closely and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Phenindione?
MediHelp rates the interaction as major. Fenoprofen and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenindione is a vitamin K antagonist, and fenoprofen impairs platelet function and can cause gastrointestinal bleeding. The combination increases the risk of serious bleeding.
How serious is the interaction between Fenoprofen and Phenindione?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs in patients taking oral anticoagulants where possible and use acetaminophen instead. If combined, monitor INR and bleeding closely and consider gastroprotection.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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