Drug interactions
Fenoprofen + Prazosin
Severity: Moderate
Fenoprofen and Prazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen may weaken the antihypertensive effect of prazosin through sodium and water retention and reduced vasodilatory prostaglandins. The effect is generally modest but can matter in patients with marginal blood pressure control.
What this interaction means in plain words
Fenoprofen and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Prazosin belongs to Genitourinary.
Why it happens
NSAID inhibition of prostaglandin synthesis causes fluid retention and vasoconstriction that oppose alpha-blocker effects.
What to do
Monitor blood pressure when starting, stopping or changing the dose of fenoprofen and titrate prazosin as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Fenoprofen with Prazosin?
MediHelp rates the interaction as moderate. Fenoprofen and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoprofen may weaken the antihypertensive effect of prazosin through sodium and water retention and reduced vasodilatory prostaglandins. The effect is generally modest but can matter in patients with marginal blood pressure control.
How serious is the interaction between Fenoprofen and Prazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting, stopping or changing the dose of fenoprofen and titrate prazosin as required.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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