Drug interactions
Fenoprofen + Propranolol
Severity: Moderate
Fenoprofen and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sustained NSAID use can reduce the antihypertensive effect of beta blockers such as propranolol, leading to higher blood pressure. Both drugs can also modestly raise potassium, though this is rarely significant alone.
What this interaction means in plain words
Fenoprofen and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Propranolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal and vascular prostaglandins causes sodium and water retention and vasoconstriction, opposing beta blocker effects.
What to do
Monitor blood pressure during regular fenoprofen use and adjust propranolol dose if control is lost. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Fenoprofen with Propranolol?
MediHelp rates the interaction as moderate. Fenoprofen and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sustained NSAID use can reduce the antihypertensive effect of beta blockers such as propranolol, leading to higher blood pressure. Both drugs can also modestly raise potassium, though this is rarely significant alone.
How serious is the interaction between Fenoprofen and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during regular fenoprofen use and adjust propranolol dose if control is lost. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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