Drug interactions
Fenoprofen + Rivastigmine
Severity: Moderate
Fenoprofen and Rivastigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rivastigmine increases gastric acid secretion through cholinergic stimulation, which may add to the ulcerogenic potential of NSAIDs like fenoprofen. This may raise the risk of gastrointestinal irritation, ulceration and bleeding.
What this interaction means in plain words
Fenoprofen and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Rivastigmine belongs to Central Nervous System.
Why it happens
Cholinesterase inhibition increases gastric acid secretion while NSAIDs reduce protective prostaglandins in the gastric mucosa.
What to do
Monitor for dyspepsia, melena and other signs of GI bleeding, and consider gastroprotection in patients with risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Rivastigmine
Frequently asked questions
Can I take Fenoprofen with Rivastigmine?
MediHelp rates the interaction as moderate. Fenoprofen and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rivastigmine increases gastric acid secretion through cholinergic stimulation, which may add to the ulcerogenic potential of NSAIDs like fenoprofen. This may raise the risk of gastrointestinal irritation, ulceration and bleeding.
How serious is the interaction between Fenoprofen and Rivastigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dyspepsia, melena and other signs of GI bleeding, and consider gastroprotection in patients with risk factors.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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