Drug interactions
Fenoprofen + Sacubitril / valsartan
Severity: Major
Fenoprofen and Sacubitril / valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce renal prostaglandin-mediated perfusion, which can cause acute kidney injury in patients taking angiotensin receptor blockers, especially in the elderly or volume depleted. They can also raise potassium and weaken blood pressure control.
What this interaction means in plain words
Fenoprofen and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
NSAID inhibition of renal prostaglandins combined with angiotensin receptor blockade reduces glomerular filtration and impairs potassium and sodium handling.
What to do
Avoid regular NSAID use where possible. If used, ensure hydration and monitor creatinine, potassium and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Sacubitril / valsartan?
MediHelp rates the interaction as major. Fenoprofen and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs reduce renal prostaglandin-mediated perfusion, which can cause acute kidney injury in patients taking angiotensin receptor blockers, especially in the elderly or volume depleted. They can also raise potassium and weaken blood pressure control.
How serious is the interaction between Fenoprofen and Sacubitril / valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible. If used, ensure hydration and monitor creatinine, potassium and blood pressure.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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