Drug interactions
Fenoprofen + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Fenoprofen and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid loss and electrolyte shifts, and volume depletion makes the kidneys more dependent on prostaglandins. NSAIDs taken around the time of the preparation raise the risk of acute kidney injury.
What this interaction means in plain words
Fenoprofen and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume depletion from bowel cleansing combined with NSAID-mediated reduction in renal prostaglandins reduces renal perfusion.
What to do
Hold fenoprofen on the day of bowel preparation and maintain hydration. Check renal function and electrolytes in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Fenoprofen and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations cause fluid loss and electrolyte shifts, and volume depletion makes the kidneys more dependent on prostaglandins. NSAIDs taken around the time of the preparation raise the risk of acute kidney injury.
How serious is the interaction between Fenoprofen and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold fenoprofen on the day of bowel preparation and maintain hydration. Check renal function and electrolytes in high-risk patients.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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