Drug interactions
Fenoprofen + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Moderate
Fenoprofen and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid shifts and electrolyte loss, and NSAIDs reduce renal perfusion and promote water retention. Taken together around a bowel prep, they can raise the risk of acute kidney injury and fluid or electrolyte disturbances such as hyponatremia.
What this interaction means in plain words
Fenoprofen and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on renal haemodynamics: NSAID prostaglandin inhibition impairs renal blood flow and water excretion while the prep causes volume depletion and electrolyte shifts.
What to do
Hold fenoprofen on the day of bowel preparation where possible and ensure adequate hydration. Check renal function and electrolytes in older patients or those with kidney disease or on diuretics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as moderate. Fenoprofen and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations cause fluid shifts and electrolyte loss, and NSAIDs reduce renal perfusion and promote water retention. Taken together around a bowel prep, they can raise the risk of acute kidney injury and fluid or electrolyte disturbances such as hyponatremia.
How serious is the interaction between Fenoprofen and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold fenoprofen on the day of bowel preparation where possible and ensure adequate hydration. Check renal function and electrolytes in older patients or those with kidney disease or on diuretics.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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