Drug interactions
Fenoprofen + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Fenoprofen and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfate-based bowel preparations can cause significant fluid and electrolyte changes, and NSAIDs can reduce renal perfusion. The combination may increase the risk of acute kidney injury, especially with dehydration.
What this interaction means in plain words
Fenoprofen and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume depletion and electrolyte shifts from the prep combine with NSAID-mediated reduction of renal prostaglandins and renal blood flow.
What to do
Avoid fenoprofen during the preparation period if feasible and maintain good oral hydration. Monitor renal function and electrolytes in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Fenoprofen and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfate-based bowel preparations can cause significant fluid and electrolyte changes, and NSAIDs can reduce renal perfusion. The combination may increase the risk of acute kidney injury, especially with dehydration.
How serious is the interaction between Fenoprofen and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid fenoprofen during the preparation period if feasible and maintain good oral hydration. Monitor renal function and electrolytes in high-risk patients.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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