Drug interactions
Fenoprofen + Tenofovir df
Severity: Moderate
Fenoprofen and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is cleared by glomerular filtration and tubular secretion and can injure the proximal tubule, while NSAIDs lower renal perfusion. Concurrent use, particularly at high or repeated NSAID doses, increases the risk of acute kidney injury and tenofovir toxicity.
What this interaction means in plain words
Fenoprofen and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from NSAID-mediated renal hypoperfusion and tenofovir tubular toxicity, with shared renal elimination.
What to do
Prefer acetaminophen or another non-NSAID option. If an NSAID is needed, use the lowest dose briefly and monitor serum creatinine and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Tenofovir df?
MediHelp rates the interaction as moderate. Fenoprofen and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir is cleared by glomerular filtration and tubular secretion and can injure the proximal tubule, while NSAIDs lower renal perfusion. Concurrent use, particularly at high or repeated NSAID doses, increases the risk of acute kidney injury and tenofovir toxicity.
How serious is the interaction between Fenoprofen and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer acetaminophen or another non-NSAID option. If an NSAID is needed, use the lowest dose briefly and monitor serum creatinine and phosphate.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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